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Other Guidelines
The management of lobular carcinoma in situ (LCIS). Is LCIS
the same as ductal carcinoma in situ (DCIS)?
Immunophenotype
All subtypes of LCIS are associated with oestrogen (ER) and
progesterone receptor (PgR) expression (60-90% of cases positive)
[17] [18].
The cells of LN also characteristically lack expression of E-cadherin, an
epithelial cell membrane molecule involved in cell-cell adhesion
[19] [20].
The cells of classic LCIS do not usually show amplification or expression of
HER-2 and expression of TP53 is uncommon
[17] [18] [21]. A
number of authors have shown differences between classic LCIS and pleomorphic
variant (PLCIS)
[22], including a higher Ki67 (proliferation) index and more frequent
expression of p53 and Her-2 in PLCIS, all of which may indicate a more
aggressive profile. PLCIS can also express GCDFP-15 (gross cystic disease fluid
protein-15), a marker of apocrine differentiation
[22] [23].
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