Isabel T. Rubio (Past President)

Clinica Universidad de Navarra
Marquesado De Santa Marta, 3
28022 Madrid, SPAIN

Biography

Isabel T. Rubio is the Head of Breast Surgical Oncology at Clinica Universidad de Navarra and Professor of Surgery at the University of Navarra in Madrid, Spain. She studied medicine at the Faculty of Medicine in Salamanca, Spain, and become a Board certified General Surgeon. She had additional training for two year as a Breast Surgical Oncology Fellow at The University of Arkansas for Medical Sciences and the Arkansas Cancer Center at Little Rock, USA and for one year at the MD Anderson Cancer Center in Houston, Texas, USA. She has been Chief of Breast Surgical Oncology at Hospital Universitario Vall d´Hebron and Associate Professor of Surgery at Universitat Autónoma de Barcelona, Spain. (2009-2018). She is the director of the Breast Surgery Fellowship program at her Institution.
Dr. Rubio is active in many societies, as EUSOMA past president (European Society of Breast Cancer Specialists), President- of the European Society of Surgical Oncology (ESSO), member of the Executive Committee at the European Cancer Organization, founding member and past President of the Spanish Association of Breast Surgeons (AECIMA), Board member of EUBREAST, and member of the SSO and the American Society of Breast Surgeons.
She is associate editor in Breast of the Journal of Surgical Oncology, and reviewer for The Breast, the European Journal of Surgical Oncology and the Annals of Surgical Oncology. She obtained the European Board of Surgery Qualification in Breast Surgery and is an officer at the UEMS Breast Surgery Division and participates as an examiner in the EBSQ Examinations in Breast Surgery.
Dr. Rubio has published over 150 peer review manuscripts and many book chapters.
Her interest is in sentinel lymph node biopsy, neoadjuvant treatments, surgical management of BRCA mutation carriers, and the role of prognostic markers (genomic profiles, liquid biopsy).
Also, her interest is focused on the standardization of Breast surgical training and Breast units.

Most relevant papers

I. Rubio
Kovacs T, Rubio IT, Markopoulos C, Audisio RA, Knox S, Kühn T, Mansel R, Matrai Z, Meani F, Nava M, Wyld L; BRESO Structure Working Group
Theoretical and practical knowledge curriculum for European Breast surgeons.
EJSO 2020; 46: 717-736.

I. Rubio
Delaloge S, Piccart M, Rutgers E, Litière S, van 't Veer LJ, van den Berkmortel F, Brain E, Dudek-Peric A, Gil-Gil M, Gomez P, Hilbers FS, Khalil Z, Knox S, Kuemmel S, Kunz G, Lesur A, Pierga JY, Ravdin P, Rubio IT, Saghatchian M, Smilde TJ, Thompson AM, Viale G, Zoppoli G, Vuylsteke P, Tryfonidis K, Poncet C, Bogaerts J, Cardoso F; MINDACT investigators and the TRANSBIG Consortium.
Standard anthracycline based versus docetaxel-capecitabine in early high clinical and/or genomic risk breast cancer in the EORTC 10041/BIG 3-04 MINDACT Phase III trial.
JCO 2020; 38(11): 1186-1197

I. Rubio
Biganzoli L, Cardoso F, Beishon M, Cameron D, Cataliotti L, Coles CE, Delgado Bolton RC, Trill MD, Erdem S, Fjell M, Geiss R, Goossens M, Kuhl C, Marotti L, Naredi P, Oberst S, Palussière J, Ponti A, Rosselli Del Turco M, Rubio IT, Sapino A, Senkus-Konefka E, Skelin M, Sousa B, Saarto T, Costa A, Poortmans P.
The requirements of a specialist breast centre.
Breast 2020; 51: 65-84

I. Rubio
Rubio IT, Rodriguez-Revuelto R, Espinosa-Bravo M, et al.
A randomized study comparing different doses of superparamagnetic iron oxide tracer for sentinel lymph node biopsy in breast cancer.
EJSO 2020; Jun 18:S0748-7983(20)30542-4

I. Rubio
Rubio IT, Kontos M, Vrancken-Peeters M, Rouzier R, Skandarajah AR, Galimberti V, Kroman N, Caballero C, Ohno S; BIG Task Force Surgical Trials.
Missed opportunities and challenges for surgical breast cancer research in the era of personalized cancer treatment.
Eur J Surg Oncol. 2019 Nov 20. pii: S0748-7983(19)31447-7. doi: 10.1016/j.ejso.2019.11.503

I. Rubio
Cardoso F, Kyriakides S, Ohno S, Penault-Llorca F, Poortmans P, Rubio IT, Zackrisson S, Senkus E; ESMO Guidelines Committee.
Early Breast Cancer:ESMO Clinical Practice Guideline for diagnosis, treatment and follow up.
Ann Oncol. 2019 Oct;30(10):1674. doi:10.1093/annonc/mdz189

I. Rubio
Rubio IT, Wyld L, Esgueva A, Kovacs T, Cardoso MJ, Leidenius M, Bianca S, Kolacinska A, Marotti L, Lecoq C, Biganzoli L, Audisio R.
Variability in breast cancer surgery training across Europe: An ESSO-EUSOMA international survey.
Eur J Surg Oncol. 2019 Apr;45(4):567-572.

I. Rubio
Valachis A, Mamounas EP, Mittendorf EA, Hayashi N, Ishitobi M, Natoli C, Fitzal F, Rubio IT, Tiezzi DG, Shin HC, Anderson SJ, Hunt KK, Matsuda N, Ohsumi S, Totomi A, Nilsson C.
Risk factors for locoregional disease recurrence after breast conserving therapy in patients with breast cancer treated with neoadjuvant chemotherapy: An international collaboration and individual patient meta-analysis.
Cancer. 2018 Jul 15;124(14):2923-2930.

I. Rubio
6. Cruz C, Castroviejo-Bermejo M, Gutiérrez-Enríquez S, Llop-Guevara A, Ibrahim YH, Gris-Oliver A, Bonache S, Morancho B, Bruna A, Rueda OM, Lai Z, Polanska UM, Jones GN, Kristel P, de Bustos L, Guzman M, Rodriguez O, Grueso J, Montalban G, Caratú G, Mancuso F, Fasani R, Jiménez J, Howat WJ, Dougherty B, Vivancos A, Nuciforo P, Serres-Créixams X, Rubio IT, Oaknin A, Cadogan E, Barrett JC, Caldas C, Baselga J, Saura C, Cortés J, Arribas J, Jonkers J, Díez O, O'Connor MJ, Balmaña J, Serra V.
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer.
Ann Oncol. 2018 Apr 4. doi: 10.1093/annonc/mdy099.

I. Rubio
Siso C, de Torres J, Esgueva-Colmenarejo A, Espinosa-Bravo M, Rus N, Cordoba O, Rodriguez R, Peg V, Rubio IT.
Intraoperative ultrasound guided excision of axillary clip in patients with node positive breast cáncer treated with neoadjuvant therapy (ILINA trial): A new tool to guide excision of the clipped node after neoadjuvant treatment.
Ann Surg Oncol. 2017 Dec 1. doi: 10.1245/s10434-017-6270-z.

I. Rubio
Cardoso F, Bartlett JMS, Slaets L, van Deurzen CHM, van Leeuwen-Stok E, Porter P, Linderholm B, Hedenfalk I, Schröder C, Martens J, Bayani J, van Asperen C, Murray M, Hudis C, Middleton L, Vermeij J, Punie K, Fraser J, Nowaczyk M, Rubio IT, Aebi S, Kelly C, Ruddy KJ, Winer E, Nilsson C, Dal Lago L, Korde L, Benstead K, Bogler O, Goulioti T, Peric A, Litière S, Aalders KC, Poncet C, Tryfonidis K, Giordano SH.
Characterization of male breast cáncer: Results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer program.
Ann Oncol. 2017 Oct 28. doi: 10.1093/annonc/mdx651.

I. Rubio
Are C, Coit DG, McMasters KM, Giuliano AE, Anderson BO, Balch CM, Pathak KA, Audisio RA, Rubio IT, Gonzalez-Moreno S, Mori M, Eguchi H, Savant D, Prasad BKCM, Cheema MA, Chaudhry ZA, Yang HK, Park DJ, Coimbra FJF, Quadros C, Said HM, Bargallo-Rocha JE.
Global fórum of cancer surgeons: Declaration of interest.
Ann Surg Oncol. 2017 Sep;24(9):2429-2431

I. Rubio
Morancho B, Zacarías-Fluck M, Esgueva A, Di Cosimo S, Prat A, Cortés J, Arribas J, Rubio IT.
Modeling anti IL-6 therapy using breast cancer derived xenografts.
Oncotarget. 2016 Sep 1. doi: 10.18632/oncotarget.11815.

I. Rubio
Cardoso F, van't Veer LJ, Bogaerts J, Slaets L, Viale G, Delaloge S, Pierga JY, Brain E, Causeret S, DeLorenzi M, Glas AM, Golfinopoulos V, Goulioti T, Knox S, Matos E, Meulemans B, Neijenhuis PA, Nitz U, Passalacqua R, Ravdin P, Rubio IT, Saghatchian M, Smilde TJ, Sotiriou C, Stork L, Straehle C, Thomas G, Thompson AM, van der Hoeven JM, Vuylsteke P, Bernards R, Tryfonidis K, Rutgers E, Piccart M; MINDACT Investigators.
70-gene signature as an aid to treatment decisions in early stage breast cancer.
N Engl J Med. 2016 Aug 25;375(8):717-29.

I. Rubio
Are C, Murthy SS, Sullivan R, Schissel M, Chowdhury S, Alatise O, Anaya D, Are M, Balch C, Bartlett D, Brennan M, Cairncross L, Clark M, Deo SVS, Dudeja V, D'Ugo D, Fadhil I, Giuliano A, Gopal S, Gutnik L, Ilbawi A, Jani P, Kingham TP, Lorenzon L, Leiphrakpam P, Leon A, Martinez-Said H, McMasters K, Meltzer DO, Mutebi M, Zafar SN, Naik V, Newman L, Oliveira AF, Park DJ, Pramesh CS, Rao S, Subramanyeshwar Rao T, Bargallo-Rocha E, Romanoff A, Rositch AF, Rubio IT, Salvador de Castro Ribeiro H, Sbaity E, Senthil M, Smith L, Toi M, Turaga K, Yanala U, Yip CH, Zaghloul A, Anderson BO.
Global Cancer Surgery: pragmatic solutions to improve cancer surgery outcomes worldwide.
Lancet Oncol. 2023 Dec;24(12):e472-e518

I. Rubio
Esgueva AJ, Sobrido C, Diaz-Botero S, Díez-Uriel E, Iscar T, De Miguel V, Regojo A, Rubio IT.
Intraoperative ultrasound margin evaluation as a tool to reduce positive superficial margins in nipple and skin sparing mastectomy in breast cancer patients.
Eur J Surg Oncol. 2023 Nov;49(11):107049

I. Rubio
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones Ma JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F.
European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Eur J Surg Oncol. 2023 Nov 27;50(1):107292

I. Rubio
Kaidar-Person O, Pfob A, Gentilini OD, Borisch B, Bosch A, Cardoso MJ, Curigliano G, De Boniface J, Denkert C, Hauser N, Heil J, Knauer M, Kühn T, Lee HB, Loibl S, Mannhart M, Meattini I, Montagna G, Pinker K, Poulakaki F, Rubio IT, Sager P, Steyerova P, Tausch C, Tramm T, Vrancken Peeters MJ, Wyld L, Yu JH, Weber WP, Poortmans P, Dubsky P.
The Lucerne Toolbox 2 to optimise axillary management for early breast cancer: a multidisciplinary expert consensus.
EClinicalMedicine. 2023 Jul 14;61:102085.

I. Rubio
Cardoso F, McCartney A, Ponti A, Marotti L, Vrieling C, Eniu A, Sousa B, Ripamonti C, Travado L, Spitz S, Jolly E, Curigliano G, Penault-Llorca F, Lecouvet F, Rubio IT, Biganzoli L.
European Society of Breast Cancer Specialists/Advanced Breast Cancer Global Alliance quality indicators for metastatic breast cancer care.
Eur J Cancer. 2023 Jul;187:105-113.

I. Rubio
Schmidt MK, Kelly JE, Brédart A, Cameron DA, de Boniface J, Easton DF, Offersen BV, Poulakaki F, Rubio IT, Sardanelli F, Schmutzler R, Spanic T, Weigelt B, Rutgers EJT.
EBCC-13 manifesto: Balancing pros and cons for contralateral prophylactic mastectomy.
Eur J Cancer. 2023 Mar;181:79-91